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2 edition of Modulation of uterine contractility and blood flow by calcium channel antagonists found in the catalog.

Modulation of uterine contractility and blood flow by calcium channel antagonists

Belainesh Desta

Modulation of uterine contractility and blood flow by calcium channel antagonists

effect of calcium channel antagonists on the responses of human and rat myometrium to oxytocics invitro....

by Belainesh Desta

  • 185 Want to read
  • 19 Currently reading

Published in Bradford .
Written in English


Edition Notes

Ph.D. thesis. Typescript.

SeriesTheses
ID Numbers
Open LibraryOL13979473M

  ) or N-type voltage-gated calcium channel (Cav) (Wilson et al. ; Agler et al. ) (Table ). There is also evi- dence that CB1 receptors can signal through Gs proteins (Chen et al. ; Glass and Felder ). Recently, Hallemeesch et al. refined such methods and were able to determine metabolic fluxes and blood flow across several organs without waste of blood. Values for liver, renal, and hindquarter blood flow by their methods were ± , ± , and ± ml 10 g body wt −1 min −1, by: A role for the renin–angiotensin system has been postulated as the fetal membranes are endowed with a functional renin–angiotensin system, and uterine ischaemia increases the production of uterine renin. , Angiotensin II can induce myometrial contractility directly or through the release of prostaglandins. When Cited by: In this thesis I show that a C-terminal fragment of CaV, an L-type voltage-gated calcium channel, translocates to the nucleus and regulates transcription. Modulation of calcium entry by the endo-lysosomal system -- Remodeling of calcium entry pathways in cancer. and that calcium influx through CRAC channels is required for creating a.

Veterinary toxicology is a very broadbased discipline with literally thousands of possible toxicants. The list was reduced using a core knowledge guidance paper written by the diplomates of the American Board of Veterinary Toxicology. (blood flow) the greater the possibility of toxin exposure to sensitive tissue. Calcium channel.


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Modulation of uterine contractility and blood flow by calcium channel antagonists by Belainesh Desta Download PDF EPUB FB2

Involvement of calcitonin gene-related peptide in the modulation of human myometrial contractility during pregnancy Article (PDF Available) in Journal of Clinical Investigation (5) Nevertheless, ion channel modulation can limit AP firing and reduce myometrial calcium flux to facilitate USM tocolysis (39, 40).

Indeed, initial evidence for CaCCs role in myometrial. BK Channel. The BK channel is a high-conductance calcium- and voltage-dependent potassium channel (Atkinson et al., ) and plays a dominant role in shaping neuronal activity and, unlike other voltage-gated ion channels, is strongly affected by alcohol (Treistman and Martin, ).

From: Handbook of Clinical Neurology, Related terms. Study Guide for Understanding Pathophysiology This page intentionally left blank Study Guide for Understanding Pathophysiology Sue E. Huether, MSN, PhD Professor Emeritus College of Nursing University of Utah Salt Lake City, Utah Kathryn L.

McCance, MSN, PhD Professor College of Nursing University of Utah Salt Lake City, Utah Section Editors Valentina L. Brashers, MD Professor Nursing. Calcium Channel Calcium Antagonist Calcium Influx Uterine Contraction Myosin Light Chain Kinase These keywords were added by machine and not by the authors.

This process is experimental and the keywords may be updated as the learning algorithm improves. To determine the biochemical pathways involved in the modulation of myometrial contractility some clinically used inhibitors may be applied to the assay, such as indomethacin (a non-selective PG receptor inhibitor), COX-2 inhibitors, atosiban (OTR inhibitor), nifedipine (calcium channel blocker), ritodrine and terbutaline (β 2-adrenergic Cited by: Objective: The purpose of our study was to characterize the membrane mechanisms responsible for oxytocin-induced depolarization in single cells from pregnant rat myometrium.

Study Design: Membrane currents were recorded with the whole-cell mode of the standard patch-clamp technique. Intracellular calcium concentration was monitored with the fluorescence from Fura 2 added to the pipette by: Effect of D.

filix-mas on high KCl-induced (80 mM) uterine contractions. Characterisation of the actions of DF to high K + solution was performed. The possibility of interaction of DF with extracellular calcium channels involved in high K + depolarisation of smooth muscles (Triggle ) was shown in Figure 5, high KCl solution produced a rapid increase in force, which was Cited by: 1.

The stimulant effects of PGF 2α on uterine contractility are also augmented by ATP via activation of P2X 1,3 receptors. Chemokines have been shown to increase (IL-1β) or decrease (IL-6) PGF 2α levels in cultures of human uterine myocytes.

The effects are mediated in part by protein kinase C, but are independent of MAPK, PLC, and IP 3 kinases. Calcium-channel blockers vasodilation and reduce cardiac contractility and heart rate. Metyrosine is a medication used to decrease catecholamine levels by inhibiting their synthesis.

Case 1 50 y/o man 4 days retroorbtial headache and diplopia. veins, ­ contractility vasoconstriction may ¯ renal, splanchnic, and cutaneous blood flow use phentolamine for ischemia due to extravasation Epinephrine a, b-1, b-2 agonist Acute hypotension (IV: mcg/kg/min), anaphylaxis (IM: – mg), septic shock (2nd line) relaxation of bronchial smooth muscle, cardiac stimulation (­ HR &File Size: KB.

Ca 2+ SENSITIZATION MECHANISM AND CONTRACTION OF SMOOTH MUSCLE. In addition to the Ca 2+-dependent activation of MLC kinase, the state of myosin light chain phosphorylation is further regulated by MLC phosphatase [aka myosin phosphatase (1, 4, 9, 11–16)], which removes the high-energy phosphate from the light chain of myosin to promote smooth muscle relaxation ().Cited by: Oxytocin infusion has been used with success to evaluate the adequacy of fetal respiratory capabilities in high-risk pregnancies of greater than 31 weeks gestation.

By inducing uterine contractions, oxytocin transiently impedes uterine blood flow. If placental reserve is low, a late deceleration in fetal heart rate may occur following oxytocin administration, indicating chronic hypoxia.

Calcium channel blockers are another group of drugs investigated in relation to dysmenorrhea treatment [54,62,63,64,65]. In general, calcium channel blockers are primarily indicated for the treatment of hypertension [62,63].

However, by reducing contractility of the vascular smooth muscles they also inhibit uterine : Zofia Barcikowska, Elżbieta Rajkowska-Labon, Magdalena Emilia Grzybowska, Rita Hansdorfer-Korzon, Ka. Recombinant Oxytocin is a synthetic cyclic peptide form of the naturally occurring posterior pituitary hormone oxytocin.

Oxytocin binds to oxytocin receptors in the uterine myometrium, which triggers the G-protein coupled receptor signal transduction cascade that causes increased intracellular calcium concentrations.

Increased calcium concentration levels activate myosin light chain kinase. Dihydropyridine Ca2+ channel blockers (CCBs) are widely accepted in the treatment of premature labour.

Their mechanism of action in tocolysis involves the blockade of L-type Ca2+ channels, influenced by the Ca2+-activated K+ channels, beta-adrenergic receptors (β-ARs) and sexual hormones. In clinical practice, most experience has been gained with the use of nifedipine, whose efficacy is Cited by: The skeletal portion of the system serves as the main storage system for calcium, phosphorus, and magnesium and contains critical components of the hematopoietic system, which is the system of organs and tissues involved in the production of blood cellular components such as corpuscles (red blood cell) and leukocytes (immune “white” blood.

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman Contents • Adrenergics • ACE inhibitors • Angiotensin receptor inhibitors • Aliskiren A • Beta blockers B • Calcium channel Blocers C • Diuretics D • Endothelial antagonists E • facilitate Vasodilation F • Ganglion blockers G Calcium-channel blockers: (Major) The depression of cardiac contractility, conductivity, and automaticity as well as the vascular dilation associated with general anesthetics may be potentiated by calcium-channel blockers.

Alternatively, general anesthetics can potentiate the hypotensive effects of calcium-channel blockers. Histone deacetylase inhibitors and an inhibitory effect on human uterine contractility. Hehir, MP,Sharkey, AM,Moynihan, AT,Europe-Finner, GN,Robson, SC,Morrison, JJ () Histone deacetylase inhibitors and an inhibitory effect on human uterine contractility.

Abstract () Novel calcium sensitizers and human uterine contractility. Again, these results are of uncertain predictive value for clinical success, because indomethacin exhibited good activity in these models. The IP antagonist, BAY (Figure 7), was effective in acutely reducing shunt vessel blood flow in a rat model of portal hypertension (Bexis et al., ); full details of its pharmacology are unavailable.

Enhanced PDF; Standard PDF ( KB) ; Introduction. The implicit paradigm that has governed much of the study of preterm parturition is that term and preterm labour are fundamentally the same process except for the gestational age at which they occur 1,2 and share a ‘common pathway’.

The uterine components of this pathway include increased uterine contractility, cervical ripening. Blaustein MP (a) Effects of internal and external cations and of ATP on sodium-calcium and calcium-calcium exchange in squid axons. Biophys J – Google Scholar Blaustein MP (b) Sodium ions, calcium ions, blood pressure regulation and hypertension: a reassessment and a by:   Calcium channel antagonists (CCA) as antihypertensives and antiarrhythmics.

The antihypertensive and antianginal effectiveness of CCA have been documented for more than 30 years. Since that time, these agents have enjoyed increasingly widespread use in the management of high blood pressure, angina pectoris, and certain cardiac by: Please read our short guide how to send a book to Kindle.

blood disease cells receptor receptors dose increased effective muscle result response risk acute tissue increase active concentrations antagonists vitamin mechanism plasma Dr.

Carl P. Weiner is a Obstetrician-Gynecologist in Kansas City, KS. Find Dr. Weiner's phone number, address, insurance information and more. This banner text can have markup. web; books; video; audio; software; images; Toggle navigation. Full text of "KDT Essentials Of Medical Pharmacology [ 7th Edition]" See other formats.

Autonomic and Cardiovascular Pharmacology PowerPoint Bookincreased blood flow Bronchial smooth muscle Agonists evoke bronchodilation, decreased airway resistance 40 decreased AP duration AV node decreased conduction velocity Ventricle decreased contractility Molecular Aspects K+ channel activation through ß-gamma Gi subunits; Gi.

A similar protective effect of ROS scavengers has been noted for vasa nervorum blood flow and NCV. The magnitude of effects possible by this approach is illustrated in Figure 3, where a high dose of the probucol analogue, BMcompletely corrected motor NCV and blood flow /5. The lung switches from low blood flow and not exchanging air to receiving large blood flow and respiring.

Respiratory abnormalities due to bronchopulmonary dysplasia, diaphragmatic hernia, antenatal hypoxia and other complications associated with pregnancy are extremely important health problems afflicting ~2% of newborns in the United States Cited by: Find link is a tool written by Edward Betts.

Longer titles found: Quantium Medical Cardiac Output () searching for Cardiac output found ( total) alternate case: cardiac output Impedance phlebography ( words) exact match in snippet view article find links to article impedance changes within the chest, as the heart beats, to calculate both cardiac output and lung water content.

adrenergic antagonists 5. angiotension-converting enzyme inhibitors 6. vasodilators/ calcium channel blockers 7. antidiuretic hormones 8. urinary acaidifiers 9. xanthine oxidase inhibitors urinary alkalizers.

The human urinary bladder is a musculomembranous hollow organ located deep in the pelvic cavity. Anatomically, the organ is divided into three major parts: the apex, body, and fundus (base), the latter consisting of the trigone and the neck (figure ).The fundus is imbedded in the prostate in males and in the musculofibrous tissue in females being intimately attached to the internal urinary.

Transcript. 1 The Toxicologist Supplement to Toxicological Sciences 54th Annual Meeting and ToxExpo TM MarchSan Diego, California The Official Journal of the Society of Toxicology ISSN VolumeIssue 1 March 2 55 th Society of Toxicology Annual Meeting and ToxExpo New Orleans, Louisiana March.

The alpha-1 (α 1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the G q heterotrimeric consists of three highly homologous subtypes, including α 1A- α 1B- and α 1D-adrenergic.

Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α 1-adrenergic receptor in the central and peripheral nervous systems. Siesjö BK, Bengtsson A. Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: A unifying hypothesis.J Cereb Blood Flow.

59 Bossmar T. et al. Receptor-mediated uterine effects of vasopressin and oxytocin in nonpregnant women. Br J Obstet Gynaecol ; (11) ; 60 Akerlund M.

Vascularization of human endometrium. Uterine blood flow in healthy condition and in primary dysmenorrhoea. Ann N Y Acad Sci ;   Animal, clinical and some epidemi-ological evidence suggests that high blood pressure is associated with abnormalities of calcium metabolism and secondary activation of the parathyroid gland.4,25 30 Hypertension The effect of calcium dietary modifications on blood pressure control has generated great controversy.

Marc Imhotep Cray, M.D. 62 Alpha-1 Adrenergic Receptor Vascular smooth muscle contraction Arterioles, veins Increased arterial resistance Decreased venous capacitance Agonists support systemic blood pressure Increased resistance Redistribution of blood toward heart, increased cardiac output Antagonists decrease blood pressure Iris Pupillary.

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens, and is the major progestogen in the body.

Progesterone has a variety of important functions in the body. It is also a crucial metabolic intermediate in the production Chemical formula: C₂₁H₃₀O₂.Aims: We investigated if the flow cytometry‐based whole blood platelet activation test (WB‐PACT) correlates with LTA or could be used as a complimentary test.

Methods: WB‐PACT quantifies αIIbβ3 activation and P‐selectin expression in response to 3 agonists and VWF binding to platelets in response to ristocetin.

In total, patients.22 Body Range Total Fluid: Blood Total Fluid: Blood Fluid of pH Concentration Ratios for Concentration Ratios for Sulfadiazine (acid, pKa Pyrimethamine (base, pKa )1 )1 Jejunum, ileum contents Stomach 85, contents Prostatic 2 secretions Vaginal